When Tolentino says you can’t “out-supplement” dysregulation, she’s challenging the idea that physiology is a simple input-output equation. Supplements may support deficiencies or specific pathways, but they rarely address the broader state of alarm that changes sleep, digestion, inflammation, and emotional reactivity all at once.
In practice, someone may add magnesium, adaptogens, or nootropics while their sleep remains fragmented and their baseline tension stays high. The result is often chasing the next product rather than stabilizing the system that determines how any product is metabolized and experienced. This transition highlights a key point: state-setting behaviors often matter more than additional substances. [...]
